La inmunización induce un periodo de diestros continuos que se extiende aproximadamente entre los días 7 y 14 del periodo experimental. La administración de α-MSH produce disminución de la producción de NO en ratas en estro y diestro, sin que se observen cambios sobre la progesterona. En el día 0 del tratamiento, los niveles de progesterona son mayores en ratas en estro que en proestro y diestro, mientras que los de NO no muestran diferencias. En este trabajo, se analiza el efecto de la α-MSH sobre la liberación de óxido nítrico (NO) y progesterona por células granulosas (GL) ováricas en cultivo a los 0, 7, 14, 21 y 28 días posteriores a la inmunización de las ratas.
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Dada su potente actividad antiinflamatoria, se considera de interés el estudio de su efecto sobre una enfermedad autoinmune, la ooforitis experimental autoinmune (EAO).
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La hormona α-estimulante de los melanocitos (α-MSH) se puede encontrar en hipófisis, cerebro, piel, ovario y otros tejidos. The results obtained suggest that α-MSH could act as a modulator of EAO, specially when the rats are in estrus. Administration of α-MSH reduced progesterone release when the rats were in proestrus and these results were correlated with an increase in NO only at day 14. At 21 and 28 days, progesterone release increased only when the rats were in proestrus, while NO production was similar to that on day 0. At the onset (day 7) and the end of this period (day 14), the NO significantly increased in estrous rats which was correlated with a reduction in progesterone concentration. The EAO rats showed a period of constant diestrus ranging from about 7 to 14 days after immunization. The administration of α-MSH induced a decrease of NO in estrus and diestrus, but did not affect progesterone release. The NO amount did not differ among the diverse days of the cycles. On day 0 the progesterone levels were higher in estrous rats than those in proestrus and diestrus. We analyzed the effect of the peptide on the release of nitric oxide (NO) and progesterone from cultured ovarian granulosa (GL) cells at 0, 7, 14, 21 and 28 days after sensitization of the rats. For this reason, we examined its effects on an autoimmune disease: the experimental autoimmune-oophoritis (EAO). Prevent this as much as possible by supplementing with enough protein and including a BCAA stack.The peptide α-melanocyte-stimulating hormone (α-MSH) occurs within the pituitary, brain, skin, ovary and other tissues, and has poten anti-inflammatory activity. If you’re depleting your body of protein for 20 hours each day, you’re likely going to lose mass. It is ESSENTIAL that if you choose to go this route, you consume lots of protein. I truly do not recommend going this route, but if you are looking to burn fat in a rapid, but stupid way, then go for it. For 20 hours in a given day, you are consuming no calories.
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28 DAYS TO ALPHA PDF PDF
Perhaps the most intense variation mentioned in this intermittent fasting plan PDF is the 20:4 variation. More on this will be covered at the end of the article. Being in a fasted state for a long period comes with the risk of losing muscle mass. The longer you fast, the faster weight is going to come off, but you should be careful with this. If you can get past the mental side of this variation, I would definitely recommend it. Obviously this variation is going to be harder because you’re consuming no calories for a longer period of time.
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If you tend to get hungry quickly, this is probably the best choice for you too.Ī slightly more challenging variation of IF involves an 18 hour fasting window and a 6 hour eating window. This variation usually works the best for people who have busy day to day lives. The most common variation of IF is to have a 16 hour fasting window and an 8 hour eating window. If you have looked into intermittent fasting at all before, you are likely aware that there are different variations.